Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
Arch Soc Esp Oftalmol ; 81(6): 315-20, 2006 Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-16804774

RESUMO

OBJECTIVE: To assess the main clinical, genetic, histopathological and ultrastructural features of Mexican patients with macular corneal dystrophy, and to compare the results with those previously reported. METHOD: We analyzed six cases where a histopathologic diagnosis of macular corneal dystrophy had been made between 1957 and 2004. RESULTS: Clinically, all corneas showed focal grayish-white stromal opacities with diffuse edges. Histopathologically, intrastromal granules stained strongly positive with Alcian blue and colloidal iron. Transmission electron microscopy showed enlargement of smooth endoplasmic reticulum and the presence of intracytoplasmic vacuoles that corresponded to glycosaminoglycans. Genetic analysis showed novel mutations in the CHST6 gene in 2 of the patients. CONCLUSIONS: Females were more affected than males and the mean age at the time of diagnosis was older than that reported previously, however the clinical, histopathological and ultrastructural features were similar to those of previous reports. As described in other cases in the literature, in some instances a disorder is found in CHST6 gene as a basis for this condition.


Assuntos
Distrofias Hereditárias da Córnea , Adulto , Distrofias Hereditárias da Córnea/diagnóstico , Distrofias Hereditárias da Córnea/enzimologia , Distrofias Hereditárias da Córnea/genética , Distrofias Hereditárias da Córnea/patologia , Distrofias Hereditárias da Córnea/ultraestrutura , Substância Própria/patologia , Feminino , Humanos , Masculino , Microscopia Eletrônica de Transmissão , Mutação , Fatores Sexuais , Sulfotransferases/genética
2.
Arch. Soc. Esp. Oftalmol ; 81(6): 315-320, jun. 2006. ilus, tab
Artigo em Es | IBECS | ID: ibc-046765

RESUMO

Objetivo: Determinar las principales característicasclínicas, histopatológicas y ultraestructurales enpacientes mexicanos con distrofia macular de lacórnea, así como las alteraciones genéticas en algunosde ellos y compararlas con lo informado en laliteratura.Método: Se recopilaron un total de seis casos condiagnóstico histopatológico de distrofia macularcorneal registrados de 1957 a 2004.Resultados: Clínicamente todas las córneas presentabanopacidades estromales blanco grisáceas debordes difusos. Histopatológicamente se demostróla presencia de depósitos finamente granularesentre las laminillas del estroma corneal, que resultaronintensamente positivos con las tinciones deazul alciano e hierro coloidal. Por microscopía electrónicade transmisión se demostró dilatación delretículo endoplásmico liso y la presencia de vacuolasintracitoplásmáticas con un material electrodenso,correspondiente a glicosaminoglicanos. El análisisgenético en dos de los pacientes demostrómutaciones en el gen CHST6. Conclusiones: En nuestra serie hubo un predominiode afección por el sexo femenino y el promediode edad fue mayor en comparación a lo informadoen la literatura. Los hallazgos clínicos, histopatológicosy ultraestructurales fueron similares a aquellospreviamente informados en otras series. Aligual que en la literatura, la alteración genética en 2de nuestros pacientes se encontró en el gen CHST6


Objective: To assess the main clinical, genetic, histopathological ;;and ultrastructural features of Mexican ;;patients with macular corneal dystrophy, and to ;;compare the results with those previously reported. ;;Method: We analyzed six cases where a histopathologic ;;diagnosis of macular corneal dystrophy had ;;been made between 1957 and 2004. ;;Results: Clinically, all corneas showed focal grayish- ;;white stromal opacities with diffuse edges. ;;Histopathologically, intrastromal granules stained ;;strongly positive with Alcian blue and colloidal ;;iron. Transmission electron microscopy showed ;;enlargement of smooth endoplasmic reticulum and ;;the presence of intracytoplasmic vacuoles that ;;corresponded to glycosaminoglycans. Genetic ;;analysis showed novel mutations in the CHST6 ;;gene in 2 of the patients. ;;Conclusions: Females were more affected than ;;males and the mean age at the time of diagnosis was ;;older than that reported previously, however the clinical, ;;histopathological and ultrastructural features ;;were similar to those of previous reports. As described in other cases in the literature, in some instances ;;a disorder is found in CHST6 gene as a basis for ;;this condition


Assuntos
Masculino , Feminino , Adulto , Humanos , Distrofias Hereditárias da Córnea/patologia , Córnea/ultraestrutura , Glicosaminoglicanos/análise , Marcadores Genéticos , Substância Própria/patologia
3.
Arch Soc Esp Oftalmol ; 81(4): 217-9, 2006 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-16688646

RESUMO

CASE REPORT: Pigmented conjunctival lesions are a diagnostic challenge for the clinician. A 37-year-old man presented with a pigmented mass involving the conjunctiva of his right eye. Clinically, a diagnosis of malignant melanoma was made and a wide excision of the tumor was performed. The histopathologic diagnosis was seborrheic keratosis. DISCUSSION: Seborrheic keratosis is a benign lesion which occurs on the eyelids and face of middle-aged and elderly individuals. The occurrence of this lesion on the conjunctiva is rare, however there are 2 cases reported in the world literature. Seborrheic keratosis should be considered in the differential diagnosis of conjunctival pigmented lesions.


Assuntos
Doenças da Túnica Conjuntiva/patologia , Ceratose Seborreica/patologia , Adulto , Túnica Conjuntiva/patologia , Túnica Conjuntiva/cirurgia , Doenças da Túnica Conjuntiva/cirurgia , Humanos , Ceratose Seborreica/cirurgia , Masculino , Procedimentos Cirúrgicos Oftalmológicos
4.
Arch. Soc. Esp. Oftalmol ; 81(4): 217-220, abr. 2006. ilus
Artigo em Es | IBECS | ID: ibc-046748

RESUMO

Caso clínico: Las lesiones conjuntivales pigmentadasrepresentan un reto diagnóstico para el clínico.Hombre de 37 años de edad quien presentó unamasa conjuntival pigmentada en su ojo derecho.Clínicamente se diagnosticó como melanoma, porlo que se realizó escisión completa del tumor. Eldiagnóstico histopatológico fue de queratosis seborreica.Discusión: La queratosis seborreica es una lesiónbenigna que se presenta en los párpados y en la carade individuos de edad media y adultos mayores. Eldesarrollo de esta lesión en la conjuntiva es pocofrecuente, solo se han informado 2 casos en la literatura.La queratosis seborreica debe ser consideradaen el diagnóstico diferencial de lesiones conjuntivalespigmentadas


Case report: Pigmented conjunctival lesions are a ;;diagnostic challenge for the clinician. A 37-yearold ;;man presented with a pigmented mass involving ;;the conjunctiva of his right eye. Clinically, a diagnosis ;;of malignant melanoma was made and a wide ;;excision of the tumor was performed. The histopathologic ;;diagnosis was seborrheic keratosis. ;;Discussion: Seborrheic keratosis is a benign lesion ;;which occurs on the eyelids and face of middleaged ;;and elderly individuals. The occurrence of this ;;lesion on the conjunctiva is rare, however there are ;;2 cases reported in the world literature. Seborrheic ;;keratosis should be considered in the differential ;;diagnosis of conjunctival pigmented lesions


Assuntos
Masculino , Adulto , Humanos , Ceratose Seborreica/cirurgia , Neoplasias da Túnica Conjuntiva/cirurgia , Diagnóstico Diferencial , Melanoma/diagnóstico , Doença de Darier/diagnóstico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...